Mercana

Merkana is recommended as a dietary supplement to the diet as an additional source of non-denatured collagen type II UC-II^TM in order to eliminate inflammation of the joints, normalize the functional state of the joints, in particular during exercise. Helps to eliminate inflammation and reduce joint stiffness, improve their mobility and flexibility.

Studies have found^1,2,3 that taking 40 mg (mg) capsules of undenatured type II collagen (UC-II^TM) daily can help relieve joint discomfort and restore healthy function and flexibility. Also, a study² found that daily intake of capsules with 40 mg (mg) of undenatured type II collagen (UC-II^TM) for 90 days under certain conditions (for example, requiring restoration of cartilage tissue) can lead to more significant changes in indicators than when using the complex glucosamine (1500 mg (mg) / day) and chondroitin (1200 mg (mg) / day).

The difference between non-denatured type II collagen and denatured (or hydrolyzed) collagen is the preservation of the three-dimensional configuration of the molecule itself (non-denatured type II collagen) and the presence of active epitopes. It is believed that undenatured type II collagen, when taken orally, penetrates from the intestinal cavity into the intestinal Peyer's patches and promotes the formation of specialized regulatory T-lymphocytes (T-regulators) that are capable of producing anti-inflammatory cytokines such as interleukin-10 (IL-10), interleukin 4 (IL-4) and transforming growth factor-β (TGF-β). These cytokines are able to penetrate into the synovial fluid of the joint through the circulatory system of the synovial membrane and subchondral bone.

Anti-inflammatory cytokines IL-10, IL-4, TGF-β are able to suppress inflammation and improve the metabolism of cartilage tissue. IL-10 affects macrophage receptors and synoviocytes, inhibiting the release of interleukin-1 (IL-1). TGF-β stimulates the synthesis of the intercellular substance (matrix) of cartilage by suppressing the catabolic activity of chondrocytes (which led to the breakdown of collagen and other extracellular matrix proteins) and activating anabolic function and proliferation of chondrocytes. In addition, IL-10 and TGF-β increase the production of interleukin-4 (IL-4). This contributes to the switching of the metabolism of chondrocytes towards the synthesis of the components of the extracellular matrix.

Undenatured collagen type II helps to reduce inflammation in the joints and improve the metabolism of articular cartilage.

* UC-II^TM and the logo are trademarks of Lonza or its affiliates.

Adults take 1 capsule 1 time a day 2 hours before or 2 hours after a meal, with a glass of drinking water. A doctor's consultation is recommended before use. The recommended period of consumption is 2-6 months. If necessary, the course can be repeated.

Do not exceed the recommended daily dose. It should not be used as a substitute for a complete diet.

Individual sensitivity to any of the components, pregnancy and lactation.

1 capsule contains the active ingredient: patented undenatured cartilage collagen type II UC-IItm * - 40.0 mg (mg) / Excipients: filler: microcrystalline cellulose (E460), anti-caking agents: calcium phosphate (E341), amorphous silicon dioxide (E551 ), magnesium stearate (E572) capsule shell: gelatin, dye: zinc oxide

Without GMO.

60 or 20 capsules in a package; Weight of contents of 1 capsule: 362 mg (mg) ‡ 7.5%.

Supplier of the active ingredient: Lonza Consumer Health Inc., USA, which is part of the Lonza company (Basel, Switzerland).

Name and location and telephone number of the manufacturer: Laboratorios Virens SL, Spain, Industria 48-B Poligono Industrial Nord-Est 08740 SantAndreu de la Barca, Barсelona., + 34-936828972.

Scientific expert assessment number  №8 of 16.02.2021.

TU U 10.8-34414427-014:2017

Do not exceed the recommended daily dose. Mercana should not be used as a replacement for a full-fledged diet.